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Clinical trials enrolling patients

Title Phase Condition Enrollees RDN Device Locations Contacts

Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity

I/IIHypertensionHeart FailureChronic Kidney DiseaseDiabetesHeart Rhythm Disorders1000Symplicity Flex Medtronic/ArdianDevice EnligHTN St. Jude MedicalParadise RecorGermanyFelix Mahfoud, MD: 4968411621346 felix.mahfoud@uks.eu Michael Böhm, MD +4968411623372 michael.boehm@uks.eu

Renal Denervation for Resistant Hypertension

IVHypertension 100Symplicity Catheter (Medtronic ®) Australia"Markus P Schlaich, MD +61 3 8532 1502 markus.schlaich@bakeridi.edu.au Petra Marusic, B.App.Sci +61 3 8532 1734 petra.marusic@bakeridi.edu.au "

Impact of Sympathetic Renal Denervation- a Study in Patients After Renal Transplantation

Not provided"•Hypertension •Chronic Kidney Disease •Renal Transplantation •Sympathetic Activity " 40Symplicity Catheter (Medtronic ®) Germany"Simon Schneider, MD . Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Unversität München"

Renal Denervation in Patients With Resistant Hypertension and Obstructive Sleep Apnea

III"•Hypertension •Obstructive Sleep Apnea " 60Symplicity Catheter (Medtronic ®) Poland"Aleksander Prejbisz, M.D., Ph.D 48223434339 aprejbisz@ikard.pl"

Renal Denervation for Complicated Hypertension

IVHypertension125Symplicity Renal Denervation CatheterAustralia"Markus P Schlaich, MD Baker IDI Heart & Diabetes Institute "

Prairie Renal Denervation Study

not providedChronic Kidney Disease50Symplicity Renal Denervation CatheterCanada"Bhanu Prasad 306-352-3018"

Renal Denervation for Management of Drug-Resistant Hypertension

IIIHypertension240Not specifiedBelgium"Jan A. Staessen, MD, PhD +32-16-347104 Alexandre Persu, MD, PhD +32-2-7642888"

Renal Denervation Therapy for Resistant Hypertension in Type 2 Diabetes Mellitus

Not provided"•Hypertension, Resistant •Diabetes Mellitus •Renal Denervation Therapy "15Symplicity Renal Denervation CatheterHong Kong" Kin Lam Tsui, FRCP (Edin, Glasg) +852 25956412 tsuikl1@ha.org.hk"

Renal Denervation in Diabetic Nephropathy

IV"•Diabetic Nephropathy •Persistent Proteinuria With Type II Diabetes "120Symplicity Renal Denervation CatheterFrance"Guillaume Bobrie, MD HTA department"

Renal Denervation by MDT-2211 System in Patients With Uncontrolled Hypertension

IIIUncontrolled Hypertension100"MDT-2211 Medtronics"Japan"Kazuyuki Shimada, MD New Oyama Municipal Hospital "

A Study of Renal Denervation in Patients With Treatment Resistant Hypertension

Not providedTreatment-Resistant Hypertension104Symplicity® Catheter SystemCanada"Harindra C. Wijeysundera 416-480-4527 harindra.wijeysundera@sunnybrook.ca Stephanie De Masi 416-864-6060 ext 7885 demasis@smh.ca"

Renal Denervation in Patients With Heart Failure and Severe Left Ventricular Dysfunction

Not providedHeart Failure50Symplicity® Catheter SystemCzech Republic" Dagmar Strnkova, Mgr +420 588 443 716 dagmarstrnkova@seznam.cz Albert Louis, MUDr. +420 588 443 238 albertlouis3@gmail.com"

"The Effect of Renal Denervation on Renal Flow in Humans "

Not providedHypertension20not providedNetherlands"Willemien L. Verloop, MD 0031 88 7559447 w.l.verloop@umcutrecht.nl "

Renal Denervation in Refractory Hypertension

IIIHypertension, Resistant to Conventional Therapy150Symplicity® Catheter SystemCzech Republic"Petr Widimsky, Prof, MD 00420267163159 petr.widimsky@fnkv.cz"

The Effect of Renal Denervation on Biological Variables

ObservationalHypertension30not providedNetherlands"Peter Blankestijn, Dr. UMC Utrecht department of Nephrology and Hypertension Eva Vink, PhD Student UMC Utrecht Department of Nephrology and Hypertension"

Renal Sympathetic Denervation for Treatment of Metabolic Syndrome Associated Hypertension (Metabolic Syndrome Study)

Not provided"•Metabolic Syndrome •Uncontrolled Hypertension "60 EnligHTN™ Renal Denervation SystemNot provided" Elizabeth Lau, PhD elau@sjm.com"

" Renal Denervation in Patients With Chronic Heart Failure & Renal Impairment Clinical Trial "

IVHeart Failure40Symplicity® Catheter SystemAustralia" K. Bogdanovich rs.medtroniccardiovascularclinicaltrials@medtronic.com"

"Observational: Renal Denervation in Treatment Resistant Hypertension "

ObservationalHypertension100Symplicity® Catheter SystemGermany"Christian Ott, MD 0049-9131-85 ext 36245 christian.ott@uk-erlangen.de"

Denervation of the REnal Artery in Metabolic Syndrome

IIIInsulin Resistance; Blood Pressure30Symplicity® Catheter SystemNetherlands"Michiel Voskuil, MD, PhD UMC Utrecht Willemien Verloop, MD UMC Utrecht"

TrAnsCatHeter Intravascular Ultrasound Energy deliVery for rEnal Denervation (ACHIEVE)

Not providedResistant Hypertension50"PARADISE percutaneous renal denervation ReCor Medical Paradise"Belgium,   Germany,   Netherlands,   Sweden,   Switzerland"Thomas Zeller, Professor Professor Universitäts-Herzzentrum Freiburg • Bad Krozingen "

Single-arm Study of Symplicity™ Renal Denervation System in Patients With Uncontrolled HyperTensioN in India

III" Adults With Uncontrolled Hypertension "45Symplicity® Catheter SystemIndia"Rajesh Radhakrishnan, Director - Clinical Studies rajesh.radhakrishnan@medtronic.com"

Multi-electrode Radiofrequency Renal Denervation System Feasibility Study

Not providedUncontrolled Hypertension50 Medtronic Multi-electrode Radiofrequency (RF) Renal Denervation Australia"K Wandrey rs.medtroniccardiovascularclinicaltrials@medtronic.com"

REnAL denervatIon by ultraSound Transcatheter Emission

Not providedResistant Hypertension20"PARADISE percutaneous renal denervation ReCor Medical Paradise"France"Xavier Girerd, Professor 01 42 17 78 33 xavier.girerd@psl.aphp.fr Gilles Montalescot, Professor 01 42 16 30 07 gilles.montalescot@psl.aphp.fr"

Renal Denervation in Treatment Resistant Hypertension

IIIHypertension70EnligHTNDenmark"Henrik Vase, MD, PhD henvas@rm.dk Ole Mathiassen, MD, PhD onm@farm.au.dk"

Renal Denervation in Patients After Acute Coronary Syndrome

III"•Acute Coronary Syndrome •Arterial Hypertension "80Not specifiedRussian Federation"Evgeny Pokushalov, MD, PhD +79139254858 e.pokushalov@gmail.com"

Study of Catheter Based Renal Denervation Therapy in Hypertension

III"•Resistant Hypertension •Renal Denervation •Ambulatory Blood Pressure •Renal Function "120Symplicity® Catheter SystemBelgium,   Germany,   Netherlands,   Sweden,   Switzerland"ARGACHA Jean francois, 33225555214 Jean.Francois.Argacha@erasme.ulb.ac.be "

Effect of Renal Denervation on NO-mediated Sodium Excretion and Plasma Levels of Vasoactive Hormones

Not providedEssential Hypertension30Not specifiedDenmark" Jesper N Bech, MD, Ph.D +45 41627639 jnbech@dadlnet.dk"

Global SYMPLICITY Registry

IV"•Hypertension •Diabetes Mellitus •Heart Failure •Chronic Kidney Disease •Sleep Apnea "5000Symplicity® Catheter SystemGermany, global"K. Wandrey rs.medtroniccardiovascularclinicaltrials@medtronic.com"

Reintervention-study After Previous Renal Denervation in Non-responding Patients With Severe Hypertension

Not provided" Hypertension, Resistant to Conventional Therapy "20Recor Paradise Ultrasound CatheterGermany, global"Roger Eckhardt 0049 69 97947653 r.eckhardt@cvcfrankfurt.de"

Renal Denervation for Treatment of Resistant Hypertension in Patients With Chronic Kidney Disease

III"•Hypertension •Chronic Kidney Disease "20Symplicity® Catheter SystemSingapore"Chieh Suai Tan, M.B.B.S +65-63214436 tan.chieh.suai@sgh.com.sg Soo Tiek Lim, M.B.B.S +65-64367521 lim.soo.teik@nhcs.com.sg "

OneShot Renal Denervation Registry

II/III"•Hypertension •Heart Failure •Diabetes Mellitus •Sleep Apnea "1000OneShot Abliation SystemItaly"Karen Krygier Karen.krygier@covidien.com"

RENABLATE Feasibility - EC12-02

I"Hypertension Renal Denervation"30Celsius® ThermoCool® RD Multi-electrode Ablation CatheterBelgium, Czech Republic, Denmark" Liesbeth Vanderlinden +32 2 7463527"

Renal Sympathetic Denervation and Insulin Sensitivity (RENSYMPIS Study)

Not providedResistant Hypertension60Not specifiedFinland"Tuomas Paana, M.D. +358 2 6277100 tuomas.paana@satshp.fi Antti Ylitalo, M.D. Ph.D +358 2 6277100 antti.ylitalo@satshp.fi "

Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction (DIASTOLE)

II/III"•Diastolic Heart Failure •Hypertension "60Not specifiedNetherlands"Willemien Verloop, MD 0031887559447 w.l.verloop@umcutrecht.nl Michiel Voskuil, MD, PhD"

Feasibility Study to Evaluate Renal Denervation Using Focused Ultrasound

Not providedHypertension50Kona MedicalAustralia, Canada, Czech Republic"Stephanie Higie shigie@konamedical.com"

Feasibility Study of Renal Denervation for the Treatment of Resistant Hypertension

Not providedUncontrolled Hypertension30"Ultrasound-based Renal Denervation Sound TX System"Czech Republic"David A. Smith dsmith@sounditv.com"

IntErnational Long-term Follow-up Study of Patients With Uncontrolled HyperTensioN (EnligHTN II)

Observational"•Hypertension •Blood Pressure "500EnligHTNAustralia, Austria, France, Germany, Greece, New Zealand, Norway, Spain, Sweden, United Kingdom"Jane Johnson jjohnson10@sjm.com"

Impact of Catecholamine Spill-over on Outcome After RDN and EP Ablation

ObservationalHypertension80Not specifiedGermany"Klaus A Tiroch, MD +49-202-896-5698 klaus.tiroch@helios-kliniken.de Jacek Szymanski, MD +49-202-896-5377 jacek.szymanski@helios-kliniken.de"

A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension

IHypertension20"Kona Medical "AustrailiaNot provided

"Observational Renal Denervation Hypertension After Stroke"

Pilot"Stroke Hypertension"25not applicableDenmark"Hanne Christensen, MD,Ph.D,DMSci Bispebjerg Hospital - Department of neurology"

Impact of Renal SympAthetic DenerVation on Chronic HypErtension

Not providedUncontrolled Hypertension500Celcium Thermacool Catheter (Biosense Webster)or Chilli II Cooled Ablation Catheter (Boston Scientific)USA"Sandeep Gangireddy, MD 212-241-6541 Sandeep.gangireddy@mssm.edu Nicole Rothman, CRC 212-241-8343 Nicole.Rothman@mountsinai.org"

Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography

Phase II"Hypertension Resistant to Conventional Therapy"60"Symplicity Catheter (Medtronic ®) The Hotman Device"Norway"Aud Høieggen, MD, PhD Oslo University Hospitl"

International First-in-Human Study of the EnligHTN Generation 2 System in Patients With Drug-resistant Uncontrolled Hypertension

Not provided"Hypertensin Renal Denervation"30EnligHTNAustrailia, New Zealand"Jane Johnson jjohnson10@sjm.com"

Renal Sympathetic Denervation for the Management of Chronic Hypertension

Not providedUncontrolled Hypertension100 Biosense Webster Celcius Thermacool catheterCzech Republic"Vivek Reddy, MD Icahn School of Medicine at Mount Sinai "

Renal Denervation in Heart Failure With Preserved Ejection Fraction

Phase IICardiac Failure40Symplicity Catheter (Medtronic ®)United Kingdom"Hitesh Patel h.patel3@rbht.nhs.uk"

Rapid Renal Sympathetic Denervation for Resistant Hypertension

Phase IIHypertension, Resistant to Conventional Therapy50Covidien OneShot" Belgium, Germany, Italy, Luxembourg, Netherlands, New Zealand ""Monica Tocchi, MD, PHD 00393931155344 medical@meditrialeurope.com"

CPVI Plus Renal Sympathetic Modification Versus CPVI Alone for AF?Atrial Fibrillation? Ablation

Not providedAtrial Fibrillation100Not providedChina"Yuehui Yin, MD 0086-13508335502"

Renal Sympathectomy in Treatment Resistant Essential Hypertension, a Sham Controlled Randomized Trial

Not providedHypertension70Symplicity Catheter (Medtronic ®)Denmark"Ole N Mathiassen, MD +45 89495566 onm@farm.au.dk Anne Kaltoft, MD, PhD +45 89495566 annekaltoft@dadlnet.dk "

Renal Nerve Ablation in Chronic Kidney Disease Patients

Observational"Hypertension Chronic Kidney Disease"100Symplicity Catheter (Medtronic ®)Germany"Christian Ott, MD +49-9131-85 ext 36245 christian.ott@uk-erlangen.de"

Adjunctive Renal Sympathetic Denervation to Modify Hypertension as Upstream Therapy in the Treatment of Atrial Fibrillation

Not provided"Uncontrolled Hypertension Atrial Fibrillation "300not providedUnited States, Czech Republic, Germany"Sandeep Gangireddy, MD 212-241-6541 sandeep.gangireddy@mountsinai.org Sam Cammack, MA, MPH 212-241-6514 sam.cammack@mountsinai.org"

Renal Sympathetic Denervation in Patients With Drug-resistant Hypertension and Symptomatic Atrial Fibrillation

Not provided"•Hypertension •Atrial Fibrillation "200Celsius Thermocool, Biosense WebsterChina"Qijun Shan, Professor 0086 025 68136407 qjshan@njmu.edu.cn"

REnal SympathetiC Denervation to sUpprEss Ventricular Tachyarrhythmias

Not providedVentricular Tachycardia220Celsius Thermocool, Biosense Webster"United States Czech Republic""Vivek Reddy, MD 212-241-7114 vivek.reddy@mountsinai.org Betsy Ellsworth, MSN, ANP 212-241-8575 betsy.ellsworth@mountsinai.org"

Renal Sympathetic Denervation as Secondary Prevention for Patients After Percutaneous Coronary Intervention.

Not providedCoronary Heart Disease600Celsius Thermocool, Biosense WebsterChina"Yuehui Yin, MD 0086-13508335502 yinyh63@163.com"

Renal Sympathetic Denervation for Patients With Chronic Heart Failure

Not providedChronic Heart Failure200Celsius Thermocool, Biosense WebsterChina"Qijun Shan, Professor 0086 025 68136407 qjshan@njmu.edu.cn"

Renal Sympathetic Denervation in Patients With Chronic Kidney Disease and Resistant Hypertension

Not providedChronic Kidney Disease100Celsius Thermocool, Biosense WebsterChina"Qijun Shan, Professor 0086 025 68136407 qjshan@njmu.edu.cn"

Effect of Catheter-based Radiofrequency Ablation Therapy in Patient With Therapy-resistant Hypertension and Sleep Apnea Syndrome

ObservationalTherapy-resistant Hypertension and Sleep Apnea20not applicableSwitzerland"Isabella Sudano, MD isabella.sudano@usz.ch Thomas Luescher, Prof MD thomas.luescher@usz.ch"

Renal Sympathetic Modification in Patients With Chronic Renal Failure

Not providedChronic Renal Failure200Celsius Thermocool, Biosense WebsterChina"Yuehui Yin, MD 0086-13508335502 yinyh63@163.com"

Renal Sympathetic Modification in Patients With Essential Hypertension

Not providedEssential Hypertension200Celsius Thermocool, Biosense WebsterChina"Yuehui Yin, MD 0086-13508335502 yinyh63@163.com"

Renal Sympathetic Modification in Patients With Heart Failure

Not providedHeart Failure200Celsius Thermocool, Biosense WebsterChina"Yuehui Yin, MD 0086-13508335502 yinyh63@163.com"

Renal Sympathetic Modification in Patients With Metabolic Syndrome

Not providedMetabolic Syndrome200Celsius Thermocool, Biosense WebsterChina"Yuehui Yin, MD 0086-13508335502 yinyh63@163.com"

Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors (Re-Shape)

Not providedHypertension, Resistant to Conventional Therapy50Not providedNorway" Terje K. Steigen, MD, PhD +4799403860 terje.steigen@unn.no Ingrid Toft, MD, PhD ingrid.toft@unn.no"

Full Length Versus Proximal Renal Arteries Ablation

Not providedHypertension, Resistant to Conventional Therapy40Celsius Thermocool, Biosense WebsterChina"Yuehui Yin, MD 0086-13508335502 yinyh63@163.com"

Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation

IIIAtrial Fibrillation; Hypertension300Not providedUnited States, Russian Federation"Evgeny Pokushalov, MD, PhD State Research Institute of Circulation Pathology Jonathan S. Steinberg, The Valley Health System and Columbia University College of Physicians & Surgeons"

REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation

Not providedVentricular Tachycardia202Not providedUSA"Sandeep Gangireddy, MD 212-241-6541 sandeep.gangireddy@mountsinai.org Evelyn Cardenas-Marin, MS, CCRP 212-659-9172 evelyn.cardenas@mssm.edu"

Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy

Not providedHypertension Secondary to Renal Disease30Not providedFinland"Juhani Koistinen, MD +35863231111 juhani.koistinen@vshp.fi"

Renal Sympathetic Denervation in Patients With Hypertension and Paroxysmal Atrial Fibrillation

Not providedHypertension; Atrial Fibrillation100not providedChina"Qijun Shan, Professor 0086 025 68136407 qjshan@njmu.edu.cn"

Renal Sympathetic Denervation in Mild Refractory Hypertension

IVRefractory Hypertension70Symplicity Catheter (Medtronic ®)Germany"Steffen Desch, MD 0049341865 ext 0 stdesch@web.de"

A Multicenter Study to Evaluate the ROX Arteriovenous Coupler in Patients With Resistant Hypertension

IIIResistant Hypertension100ROX COUPLERBelgium, Germany, Greece, Ireland, Netherlands, Poland, United KingdomCountry wise contact

Renal Denervation in Patients With Uncontrolled Hypertension - SYMPLICITY HTN-4

IIIHypertension Vascular Diseases Cardiovascular Diseases580SymplicityUnited StatesMaria Parke rs.htn-4ctgov@medtronic.com Keri Wandrey rs.medtroniccardiovascularclinicaltrials@medtronic.com

Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation

Feasibility StudyAtrial Fibrillation Hypertension40not providedUnited StatesNot Provided

Single-arm Study of Symplicity™ Renal Denervation System in Patients With Uncontrolled HyperTensioN in India

IIIAdults With Uncontrolled Hypertension45SymplicityIndia Rajesh Radhakrishnan rajesh.radhakrishnan@medtronic.com

The Effects of Renal Denervation on Insulin Sensitivity

not providedTreatment Resistant Essential Hypertension Insulin Resistance8not providedDenmarkNot Provided

Renal Denervation in Patients With Uncontrolled Blood Pressure

not providedBlood Pressure20Renal Denervation is performed using the Beta-Cath 3.5F to a deliver radiation dose 25 Gy to the renal artery. Radiation: Radiation Dose 50 Gy Renal Denervation is performed using the Beta-Cath 3.5F to a deliver radiation dose 50 Gy to the renal artery. United StatesRon Waksman 202-877-5975 ron.waksman@medstar.net

Comparison of Redo PVI With vs. Without Renal Denervation for Recurrent AF After Initial PVI

IIAtrial Fibrillation; Arterial Hypertension60Procedure: Redo PVI Procedure: PVI + RDNRussian Federation: Evgeny Pokushalov, MD, PhD +79139254858 e.pokushalov@gmail.com

A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension

IHypertension20Kona UltrasoundAustraliaNot Provided

Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography

IIHypertension, Resistant to Conventional Therapy60The SymplicityTM Renal Denervation System; Device: The HOTMAN® System Norwaynot provided

CPVI Plus Renal Sympathetic Modification Versus CPVI Alone for AF?Atrial Fibrillation? Ablation

Not providedAtrial Fibrillation100CPVI plus renal sympathetic modification; Procedure: CPVI ChinaYuehui Yin, MD 0086-13508335502 yinyh63@163.com

Radiofrequency Ablation for ADPKD Blood Pressure and Disease Progression Control

IIAutosomal Dominant Polycystic Kidney Disease; Hypertension100Procedure: renal sympathetic denervation; Drug: antihypertensive drugs China Changlin Mei, MD +86 21 81885391 chlmei1954@126.com Yiyi Ma, Master +8613661679863 dukemm@126.com

Renal Sympathectomy in Treatment Resistant Essential Hypertension, a Sham Controlled Randomized Trial

not providedHypertension70Procedure: Renal artery ablation (Symplicity); Procedure: Renal angiographyDenmark Ole N Mathiassen, MD, PhD +45 89495566 onm@farm.au.dk Anne Kaltoft, MD, PhD +45 89495566 annekaltoft@dadlnet.dk

Continued Safety and Performance of the TIVUS System

II/IIIHypertension, Resistant to Conventional Therapy80TivusAustraliaTami Abudi 972525989833 tami@cardiosonic.co.il

Adjunctive Renal Sympathetic Denervation to Modify Hypertension as Upstream Therapy in the Treatment of Atrial Fibrillation

Not ProvidedUncontrolled Hypertension; Atrial Fibrillation300renal denervaationCzech Republic, Germany Sam Commack, MA, MPH 212-241-6541 sam.cammack@mountsinai.org Betsy Ellsworth, MSN 212-824-8902 betsy.ellsworth@mountsinai.org

Renal Sympathetic Denervation in Patients With Drug-resistant Hypertension and Symptomatic Atrial Fibrillation

Not providedHypertension; Atrial Fibrillation200renal denervation (not provided)ChinaQijun Shan, professor 0086 025 68136407 qjshan@njmu.edu.cn

Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors

Not providedHypertension, Resistant to Conventional Therapy50Renal sympathetic denervationNorwayTerje K. Steigen, MD, PhD +4799403860 terje.steigen@unn.no Ingrid Toft, MD, PhD ingrid.toft@unn.no

Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy

not providedHypertension Secondary to Renal Disease30 Renal nerve denervationFinlandJuhani Koistinen, MD +35863231111 juhani.koistinen@vshp.fi

Disclaimer: This site is meant for educational purposes only, no medical advice is given or implied. Renal denervation is still an experimental treatment in many parts of the world, including the United States.